- Title
- Birth Outcomes After Pertussis and Influenza Diagnosed in Pregnancy: A Retrospective, Population-Based Study
- Creator
- Frawley, Jane E.; He, Wen-Qiang; McCallum, Lisa; McIntyre, Peter; Hayen, Andrew; Gidding, Heather; Sullivan, Elizabeth; Liu, Bette
- Relation
- BJOG: An International Journal of Obstetrics and Gynaecology Vol. 132, Issue 3, p. 335-364
- Publisher Link
- http://dx.doi.org/10.1111/1471-0528.17984
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2025
- Description
- Objective: Adverse birth outcomes and the maternal severity of influenza in pregnancy are well documented but information on pertussis is limited. Design: Population-based linkage data were collected during 2001–2016. Setting: New South Wales, Australia. Population or Sample: A total of 1 453 037 singleton births. Methods: Cox regression was used to estimate the associations between pertussis or influenza during pregnancy and birth outcomes with adjustment of covariates. Main Outcome Measures: Adverse birth outcomes (preterm birth and low birth weight). Results: Among 1 453 037 singleton births over 16 years, we identified pertussis in 925 (49; 5.3% hospitalised) and influenza in 2850 (1092; 38.3% hospitalised) women during pregnancy. Cases of pertussis were similarly distributed by trimester (32% 3rd) whereas 46% of influenza cases were in the 3rd trimester. Younger age, previous birth, and being overseas-born were associated with both pertussis and influenza, whereas identifying as Aboriginal or Torres Strait Islander, hypertension or diabetes before and during pregnancy, and a number of other factors were only associated with influenza. Both pertussis and influenza in pregnancy were associated with increased risk of preterm birth (pertussis: aHR = 1.30, 95% CI 1.01–1.68; influenza: aHR = 1.56, 95% CI 1.36–1.79) and these increased risks were greater when infections in the period within 2 weeks of birth were considered (pertussis: aHR = 2.36, 95% CI 1.26–4.41; influenza: aHR = 2.29, 95% CI 1.78–2.96). Conclusions: Maternal pertussis and influenza infections close to the time of birth were associated with adverse birth outcomes. These findings highlight the benefits of vaccination during pregnancy.
- Subject
- infection; newborn; respiratory; vaccine; whooping cough; SDG 3; Sustainable Development Goal
- Identifier
- http://hdl.handle.net/1959.13/1517718
- Identifier
- uon:57156
- Identifier
- ISSN:1470-0328
- Language
- eng
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