Interferon-epsilon is a novel regulator of NK cell responses in the uterus

Mayall, Jemma R.; Horvat, Jay C.; de Geus, Eveline D.; Starkey, Malcolm R.; Kim, Richard Y.; Daly, Katie; Goggins, Bridie J.; Keely, Simon; Maltby, Steven; Baldwin, Rennay; Foster, Paul S.; Boyle, Michael J.; Mangan, Niamh E.; Tanwar, Pradeep S.; Huntington, ND; Hertzog, PJ; Hansbro, Philip M.; Chevalier, Anne; McCarthy, Huw; Hampsey, Daniel; Donovan, Chantal; Brown, Alexandra C.; Matthews, Antony Y.; de Weerd, Nicole A.

Title: Interferon-epsilon is a novel regulator of NK cell responses in the uterus
Creator: Mayall, Jemma R.; Horvat, Jay C.; de Geus, Eveline D.; Starkey, Malcolm R.; Kim, Richard Y.; Daly, Katie; Goggins, Bridie J.; Keely, Simon; Maltby, Steven; Baldwin, Rennay; Foster, Paul S.; Boyle, Michael J.; Mangan, Niamh E.; Tanwar, Pradeep S.; Huntington, ND; Hertzog, PJ; Hansbro, Philip M.; Chevalier, Anne; McCarthy, Huw; Hampsey, Daniel; Donovan, Chantal; Brown, Alexandra C.; Matthews, Antony Y.; de Weerd, Nicole A.
Relation: NHMRC.1059242 http://purl.org/au-research/grants/nhmrc/1059242 & 1003591 http://purl.org/au-research/grants/nhmrc/1003591 & 1079187 http://purl.org/au-research/grants/nhmrc/1079187
Relation: EMBO Molecular Medicine Vol. 16, Issue 2, p. 267-293
Publisher Link: http://dx.doi.org/10.1038/s44321-023-00018-6
Publisher: Wiley-Blackwell
Resource Type: journal article
Date: 2024
Description: The uterus is a unique mucosal site where immune responses are balanced to be permissive of a fetus, yet protective against infections. Regulation of natural killer (NK) cell responses in the uterus during infection is critical, yet no studies have identified uterine-specific factors that control NK cell responses in this immune-privileged site. We show that the constitutive expression of IFNε in the uterus plays a crucial role in promoting the accumulation, activation, and IFNγ production of NK cells in uterine tissue during Chlamydia infection. Uterine epithelial IFNε primes NK cell responses indirectly by increasing IL-15 production by local immune cells and directly by promoting the accumulation of a pre-pro-like NK cell progenitor population and activation of NK cells in the uterus. These findings demonstrate the unique features of this uterine-specific type I IFN and the mechanisms that underpin its major role in orchestrating innate immune cell protection against uterine infection.
Subject: interferon-epsilon; type I interferon; natural killer cell; female reproductive tract; chlamydia infection
Identifier: http://hdl.handle.net/1959.13/1505685
Identifier: uon:55703
Identifier: ISSN:1757-4676
Language: eng
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