- Title
- Investigating the effects of PFOA accumulation and depuration on specific phospholipids in zebrafish through imaging mass spectrometry
- Creator
- Shi, Qiuyue; Wan, Zhengfen; Lu, Shaoyong; Fang, Cheng; Yan, Changzhou; Zhang, Xian
- Relation
- Environmental Science: Processes & Impacts Vol. 26, Issue 4, p. 700-709
- Publisher Link
- http://dx.doi.org/10.1039/d3em00413a
- Publisher
- Royal Society of Chemistry
- Resource Type
- journal article
- Date
- 2024
- Description
- Perfluorooctanoic acid (PFOA) is an emerging persistent organic pollutant. Exposure to PFOA was observed to have a correlation with the expression levels of phospholipids. However, there are currently no studies that directly visualize the effects of PFOA on phospholipids. To this end, matrix-assisted laser desorption/ionization time of flight imaging mass spectrometry (MALDI-TOF-IMS) was used to visualize changes in phospholipids in the different tissues of zebrafish following exposure to PFOA. This study found that the major perturbed phospholipids were phosphatidylcholine (PC), diacylglycerol (DG), phosphatidic acid (PA), phosphatidylglycerol (PG), sphingomyelin (SM), and triacylglycerol (TG). These perturbed phospholipids caused by PFOA were reversible in some tissues (liver, gill, and brain) and irreversible in others (such as the highly exposed intestine). Moreover, the spatial distribution of perturbed phospholipids was mainly located around the edge or center of the tissues, implying that these tissue regions need special attention. This study provides novel insight into the biological toxicity and toxicity mechanisms induced by emerging environmental pollutants.
- Subject
- organic pollutant; zebrafish; biological toxicity; toxicity mechanisms; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1503573
- Identifier
- uon:55357
- Identifier
- ISSN:2050-7895
- Language
- eng
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