- Title
- A review of current therapeutics targeting the mitochondrial protease ClpP in diffuse midline glioma, H3 K27-altered
- Creator
- Jackson, Evangeline R.; Persson, Mika L.; Fish, Cameron J.; Findlay, Izac J.; Mueller, Sabine; Nazarian, Javad; Hulleman, Esther; van der Lugt, Jasper; Duchatel, Ryan J.; Dun, Matthew D.
- Relation
- Neuro-Oncology Vol. 26, Issue Supplement 2, p. S136-S154
- Publisher Link
- http://dx.doi.org/10.1093/neuonc/noad144
- Publisher
- Oxford University Press
- Resource Type
- journal article
- Date
- 2024
- Description
- Diffuse midline gliomas (DMGs) are devastating pediatric brain tumors recognized as the leading cause of cancer related death in children. DMGs are high-grade gliomas (HGGs) diagnosed along the brain’s midline. Euchromatin is the hallmark feature of DMG, caused by global hypomethylation of H3K27 either through point mutations in histone H3 genes (H3K27M), or by overexpression of the enhancer of zeste homolog inhibitory protein. In a clinical trial for adults with progressive HGGs, a 22-year-old patient with a thalamic DMG, H3 K27-altered, showed a remarkable clinical and radiological response to dordaviprone (ONC201). This response in an H3 K27-altered HGG patient, coupled with the lack of response of patients harboring wildtype-H3 tumors, has increased the clinical interest in dordaviprone for the treatment of DMG. Additional reports of clinical benefit have emerged, but research defining mechanisms of action (MOA) fall behind dordaviprone’s clinical use, with biomarkers of response unresolved. Here, we summarize dordaviprone’s safety, interrogate its preclinical MOA identifying the mitochondrial protease “ClpP” as a biomarker of response, and discuss other ClpP agonists, expanding the arsenal of potential weapons in the fight against DMG. Finally, we discuss combination strategies including ClpP agonists, and their immunomodulatory effects suggestive of a role for the tumor microenvironment in DMG patient response.
- Subject
- diffuse midline glioma (DMG); dordaviprone; ONC201; CLPP; CLPP agonist
- Identifier
- http://hdl.handle.net/1959.13/1503355
- Identifier
- uon:55315
- Identifier
- ISSN:1522-8517
- Rights
- x
- Language
- eng
- Reviewed
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