- Title
- Durable plasma-mediated zwitterionic grafting on polymeric surfaces for implantable medical devices
- Creator
- Crago, Matthew; Tan, Richard; Hung, Juichien; Wise, Steven G.; Akhavan, Behnam; Bilek, Marcela; Dehghani, Fariba; Talebian, Sepehr; Naficy, Sina
- Relation
- ARC.DP200102164
- Relation
- Communications Materials Vol. 5, Issue 1, no. 24
- Publisher Link
- http://dx.doi.org/10.1038/s43246-024-00462-y
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2024
- Description
- Adverse body reactions to blood-contacting medical devices endanger patient safety and impair device functionality, with events invariably linked to nonspecific protein adsorption due to suboptimal material biocompatibility. To improve the safety and durability of such devices, herein we propose a strategy for introducing stable zwitterionic grafts onto polymeric surfaces via plasma functionalization. The resulting zwitterion-grafted substrates exhibit long-lasting superhydrophilicity, enabling antifouling and anti-thrombogenic properties. We demonstrate the successful modification of the surface elemental composition, morphology, and hydrophilicity, while retaining the underlying mechanical properties of the polymeric substrate. Furthermore, we optimise the fabrication process to ensure long-lasting modifications at least three months after fabrication. This strategy decreases fibrinogen adsorption by approximately 9-fold, and thrombosis by almost 75% when applied to a commercial polyurethane. Moreover, this process is universally applicable to a wide range of polymeric materials, even those with stable chemistry such as polytetrafluoroethylene.
- Subject
- biocompatibility; hydrophilicity; morphology; polymeric materials; plasma functionalization; substrates
- Identifier
- http://hdl.handle.net/1959.13/1501849
- Identifier
- uon:55176
- Identifier
- ISSN:2662-4443
- Rights
- © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Language
- eng
- Full Text
- Reviewed
- Hits: 2563
- Visitors: 2561
- Downloads: 4
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 4 MB | Adobe Acrobat PDF | View Details Download |