- Title
- A pro-inflammatory diet is associated with long-term depression and anxiety levels but not fatigue in people with multiple sclerosis
- Creator
- Saul, A.; Taylor, B. V.; Lechner-Scott, J.; van der Mei, I.; Blizzard, L.; Simpson-Yap, S.; Oddy, W. H.; Shivappa, N.; Hebert, J. R.; Black, L. J.; Ponsonby, A. L.; Broadley, S. A.
- Relation
- Multiple Sclerosis and Related Disorders Vol. 84, Issue April 2024, no. 105468
- Publisher Link
- http://dx.doi.org/10.1016/j.msard.2024.105468
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2024
- Description
- Background: Multiple sclerosis is characterised by acute and chronic inflammation in the CNS. Diet may influence inflammation, and therefore MS outcomes. Objective: To determine whether the Dietary Inflammatory Index (DII®)) is associated with depression, anxiety, and fatigue in a prospective cohort of people with MS. Methods: People with a first clinical diagnosis of demyelination were followed over 10 years (n=223). DII and energy-adjusted DII (E-DIITM) scores were calculated from the dietary intake in the preceding 12 months measured by food frequency questionnaire. Depression and anxiety were assessed by the Hospital Anxiety and Depression Scale (HADS-A and HADS-D, respectively), and fatigue by the Fatigue Severity Scale. Results: A higher E-DII score was associated with higher levels of depression and anxiety five years later (e.g., highest vs lowest E-DII quartile, HADS-D score: β=2.23, 95%CI=0.98,3.48, p<0.001; HADS-A score: β=1.90, 95%CI=0.59,3.21, p<0.001). A cumulative E-DII score was associated with depression (p<0.01) and anxiety (p=0.05) at the 10-year review. No associations were seen for fatigue. Conclusion: Our findings suggest that, in people with MS, a more pro-inflammatory diet may long-term adverse impact on depression and anxiety, but not fatigue.
- Subject
- diet; inflammation; Dietary Inflammatory Index; multiple sclerosis; depression; anxiety
- Identifier
- http://hdl.handle.net/${Handle}
- Identifier
- uon:54877
- Identifier
- ISSN:2211-0348
- Rights
- x
- Language
- eng
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