- Title
- Utilising Nanozymatic Activity of Copper-Functionlized Mesoporous C3N5 for Sensing of Biomolecules
- Creator
- Patel, Vaishwik; Ramadass, Kavitha; Vinu, Ajayan; Morrison, Brodie; Britto, Jolitta Sheri John; Lee, Jang Mee; Mahasivam, Sanje; Weerathunge, Pabudi; Bansal, Vipul; Yi, Jiabao; Singh, Gurwinder
- Relation
- Chemistry - A European Journal Vol. 29, Issue 69, no. e202302723
- Publisher Link
- http://dx.doi.org/10.1002/chem.202302723
- Publisher
- Wiley-VCH Verlag GmbH & Co. KGaA
- Resource Type
- journal article
- Date
- 2023
- Description
- Designing unique nanomaterials for the selective sensing of biomolecules is of significant interest in the field of nanobiotechnology. In this work, we demonstrated the synthesis of ordered Cu nanoparticle-functionalised mesoporous C3N5 that has unique peroxidase-like nanozymatic activity for the ultrasensitive and selective detection of glucose and glutathione. A nano hard-templating technique together with the in-situ polymerisation and self-assembly of Cu and high N-containing CN precursor was adopted to introduce mesoporosity as well as high N and Cu content in mesoporous C3N5. Due to the ordered structure and highly dispersed Cu in the mesoporous C3N5, a large enhancement of the peroxidase mimetic activity in the oxidation of a redox dye in the presence of hydrogen peroxide could be obtained. Additionally, the optimised Cu-functionalised mesoporous C3N5 exhibited excellent sensitivity to glutathione with a low detection limit of 2.0 ppm. The strong peroxidase activity of the Cu-functionalised mesoporous C3N5 was also effectively used for the sensing of glucose with a detection limit of 0.4 mM through glucose oxidation with glucose oxidase. This unique Cu-functionalised mesoporous C3N5 has the potential for detecting various molecules in the environment as well as for next-generation glucose and glutathione diagnostic devices.
- Subject
- colorimetric detection; enzyme mimetic activity; functionalised mesoporous carbon nitride; glucode and glutathione sensing; higher nitrogen content
- Identifier
- http://hdl.handle.net/1959.13/1496197
- Identifier
- uon:54159
- Identifier
- ISSN:0947-6539
- Rights
- x
- Language
- eng
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