- Title
- Rutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: A PCR validation
- Creator
- Mehta, Meena; Paudel, Keshav Raj; Chellappan, Dinesh Kumar; Dua, Kamal; Shukla, Shakti D.; Shastri, Madhur D.; Satija, Saurabh; Singh, Sachin Kumar; Gulati, Monica; Dureja, Harish; Zacconi, Flavia C.; Hansbro, Philip M.
- Relation
- Future Medicinal Chemistry Vol. 13, Issue 6, p. 543-549
- Publisher Link
- http://dx.doi.org/10.4155/fmc-2020-0297
- Publisher
- Future Science Ltd.
- Resource Type
- journal article
- Date
- 2021
- Description
- Aim: In the present study, the inhibitory potential of rutin-loaded liquid crystalline nanoparticles (LCNs) on oxidative stress was determined in human bronchial epithelial cells (BEAS-2B) by analysing the expression levels of different antioxidant (NADPH quinine oxidoreductase-1 (NQO1); γ-glutamyl cysteine synthetase catalytic subunit (GCLC)) and pro-oxidant (NADPH oxidase (Nox)-4; Nox2B) genes. Results: Our findings revealed that the rutin-loaded LCNs inhibited the genes, namely Nox2B and Nox4, which caused oxidative stress. In addition, these nanoparticles demonstrated an upregulation in the expression of the antioxidant genes Gclc and Nqo-1 in a dose-dependent manner. Conclusion: The study indicates the promising potential of rutin-loaded LCNs as an effective treatment strategy in patients with high oxidant loads in various respiratory diseases.
- Subject
- antioxidant; inflammation; lipopolysaccharide; oxidative stress genes; rutin; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1493750
- Identifier
- uon:53640
- Identifier
- ISSN:1756-8919
- Language
- eng
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