- Title
- A paraventricular thalamus to insular cortex glutamatergic projection gates "emotional" stress-induced binge eating in females
- Creator
- Anversa, Roberta G.; Campbell, Erin J.; Walker, Leigh C.; Ch'ng, Sarah S.; Muthmainah, Muthmainah; Kremer, Frederico S.; Guimarães, Amanda M.; O'Shea, Mia J.; He, Suheng; Dayas, Christopher V.; Andrews, Zane B.; Lawrence, Andrew J.; Brown, Robyn M.
- Relation
- Neuropsychopharmacology Vol. 48, Issue 20 July 2023, p. 1931-1940
- Publisher Link
- http://dx.doi.org/10.1038/s41386-023-01665-6
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2023
- Description
- It is well-established that stress and negative affect trigger eating disorder symptoms and that the brains of men and women respond to stress in different ways. Indeed, women suffer disproportionately from emotional or stress-related eating, as well as associated eating disorders such as binge eating disorder. Nevertheless, our understanding of the precise neural circuits driving this maladaptive eating behavior, particularly in women, remains limited. We recently established a clinically relevant model of 'emotional' stress-induced binge eating whereby only female mice display binge eating in response to an acute "emotional" stressor. Here, we combined neuroanatomic, transgenic, immunohistochemical and pathway-specific chemogenetic approaches to investigate whole brain functional architecture associated with stress-induced binge eating in females, focusing on the role of Vglut2 projections from the paraventricular thalamus (PVTVglut2+) to the medial insular cortex in this behavior. Whole brain activation mapping and hierarchical clustering of Euclidean distances revealed distinct patterns of coactivation unique to stress-induced binge eating. At a pathway-specific level, PVTVglut2+ cells projecting to the medial insular cortex were specifically activated in response to stress-induced binge eating. Subsequent chemogenetic inhibition of this pathway suppressed stress-induced binge eating. We have identified a distinct PVTVglut2+ to insular cortex projection as a key driver of "emotional" stress-induced binge eating in female mice, highlighting a novel circuit underpinning this sex-specific behavior.
- Subject
- stress; emotional; binge eating; females; vesicular glutamate transporter 2; chemogenetic
- Identifier
- http://hdl.handle.net/1959.13/1491448
- Identifier
- uon:53155
- Identifier
- ISSN:0893-133X
- Rights
- © The Author(s) 2023. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Language
- eng
- Full Text
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