- Title
- Reduced Skeletal Muscle Mass Is Associated with an Increased Risk of Asthma Control and Exacerbation
- Creator
- Zhang, Shuwen; Zhang, Xin; Cheng, Gaiping; Gibson, Peter G.; Oliver, Brian G.; Luo, Fengming; McDonald, Vanessa M.; Li, Weimin; Wang, Gang; Deng, Ke; Wang, Changyong; Wood, Lisa G.; Wan, Huajing; Liu, Lei; Wang, Ji; Zhang, Li; Liu, Ying
- Relation
- Journal of Clinical Medicine Vol. 11, Issue 23, no. 7241
- Publisher Link
- http://dx.doi.org/10.3390/jcm11237241
- Publisher
- MDPI
- Resource Type
- journal article
- Date
- 2022
- Description
- Background: Skeletal muscle mass (SMM) has been suggested to be associated with multiple health-related outcomes. However, the potential influence of SMM on asthma has not been largely explored. Objective: To study the association between SMM and clinical features of asthma, including asthma control and exacerbation, and to construct a model based on SMM to predict the risk of asthma exacerbation (AEx). Methods: In this prospective cohort study, we consecutively recruited patients with asthma (n = 334), classified as the SMM Normal group (n = 223), SMM Low group (n = 88), and SMM High group (n = 23). We investigated the association between SMM and clinical asthma characteristics and explored the association between SMM and asthma control and AEx within a 12-month follow-up period. Based on SMM, an exacerbation prediction model was developed, and the overall performance was externally validated in an independent cohort (n = 157). Results: Compared with the SMM Normal group, SMM Low group exhibited more airway obstruction and worse asthma control, while SMM High group had a reduced eosinophil percentage in induced sputum. Furthermore, SMM Low group was at a significantly increased risk of moderate-to-severe exacerbation compared with the SMM Normal group (relative risk adjusted 2.02 [95% confidence interval (CI), 1.35–2.68]; p = 0.002). In addition, a model involving SMM was developed which predicted AEx (area under the curve: 0.750, 95% CI: 0.691–0.810). Conclusions: Low SMM was an independent risk factor for future AEx. Furthermore, a model involving SMM for predicting the risk of AEx in patients with asthma indicated that assessment of SMM has potential clinical implications for asthma management.
- Subject
- asthma; skeletal muscle mass; exacerbation; clinical prediction model; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1489795
- Identifier
- uon:52770
- Language
- eng
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