Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency

Title: Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency
Creator: Simone, Michela I.; Wood, Adam; Campkin, David; Kiefel, Milton J.; Houston, Todd A.
Relation: European Journal of Medicinal Chemistry Vol. 235, no. 114282
Publisher Link: http://dx.doi.org/10.1016/j.ejmech.2022.114282
Publisher: Elsevier Masson
Resource Type: journal article
Date: 2022
Description: This review covers the literature in the past 15 years on glycosidase inhibitors lacking a basic nitrogen (for example iminosugars/azasugars) with a focus on natural terpenoids, and mono- and polycyclic aromatic hydrocarbons. From quite diverse structures, insight into inhibitor structural features that may be applicable to optimisation of all glycosidase inhibitors including iminosugars are identified.
Subject: benzimidazole; chalcone; cinnamic acid; coumarin; flavonoid
Identifier: http://hdl.handle.net/1959.13/1489759
Identifier: uon:52765
Language: eng
Reviewed

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