Roles of vimentin in health and disease

Title: Roles of vimentin in health and disease
Creator: Ridge, Karen M.; Eriksson, John E.; Pekny, Milos; Goldman, Robert D.
Relation: Genes and Development Vol. 36, p. 391-407
Publisher Link: http://dx.doi.org/10.1101/gad.349358.122
Publisher: Cold Spring Harbor Laboratory Press
Resource Type: journal article
Date: 2022
Description: More than 27 yr ago, the vimentin knockout (Vim-/-) mouse was reported to develop and reproduce without an obvious phenotype, implying that this major cytoskeletal protein was nonessential. Subsequently, comprehensive and careful analyses have revealed numerous phenotypes in Vim-/- mice and their organs, tissues, and cells, frequently reflecting altered responses in the recovery of tissues following various insults or injuries. These findings have been supported by cell-based experiments demonstrating that vimentin intermediate filaments (IFs) play a critical role in regulating cell mechanics and are required to coordinate mechanosensing, transduction, signaling pathways, motility, and inflammatory responses. This review highlights the essential functions of vimentin IFs revealed from studies of Vim-/- mice and cells derived from them.
Subject: intermediate filaments; vimentin; vimentin-null mouse; mice; SDG 3; Sustainable Development Goals
Identifier: http://hdl.handle.net/1959.13/1487582
Identifier: uon:52190
Identifier: ISSN:0890-9369
Rights: x
Language: eng
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