- Title
- Poly-immunoglobulin receptor-mediated transport of IgA into the male genital tract is important for clearance of chlamydia muridarum infection
- Creator
- Cunningham, Kelly A.; Carey, Alison J.; Finnie, Jane M.; Bao, Shisan; Coon, Chamere; Jones, Russell; Wijburg, Odilia; Strugnell, Richard A.; Timms, Peter; Beagley, Kenneth W.
- Relation
- American Journal of Reproductive Immunology Vol. 60, Issue 5, p. 405-414
- Publisher Link
- http://dx.doi.org/10.1111/j.1600-0897.2008.00637.x
- Publisher
- John Wiley
- Resource Type
- journal article
- Date
- 2008
- Description
- Problem: Chlamydia trachomatis is the most common sexually transmitted infection worldwide. While infection in females requires a Th1 response for clearance, such a response in males may disrupt the immune privileged nature of the male reproductive tract, potentially contributing to infertility. Method of study: We investigated the role of IgA in protection against an intrapenile Chlamydia muridarum infection of C57BL ⁄ 6 and pIgR) ⁻⁄⁻ ) mice. Results: Here, we show that the poly immunoglobulin receptor is the main pathway for IgA transport into the male reproductive tract. The high levels of IgA seen in prostatic fluid of wild-type mice correlate with reduction in chlamydial infection both in vitro and in vivo. Conclusion: These findings indicate that a Chlamydia vaccine that induces neutralizing IgA in the prostate will aid in the protection against infection in males.
- Subject
- chlamydia; IgA; poly-immunoglobulin receptor
- Identifier
- uon:5204
- Identifier
- http://hdl.handle.net/1959.13/43075
- Identifier
- ISSN:1046-7408
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