- Title
- Targeting the two-pore channel 2 in cancer progression and metastasis
- Creator
- Skelding, Kathryn A.; Barry, Daniel L.; Theron, Danielle Z.; Lincz, Lisa F.
- Relation
- Exploration of Targeted Anti-tumor Therapy Vol. 3, Issue 28 February 2022, p. 62-89
- Publisher Link
- http://dx.doi.org/10.37349/etat.2022.00072
- Publisher
- Open Exploration
- Resource Type
- journal article
- Date
- 2022
- Description
- The importance of Ca2+ signaling, and particularly Ca2+ channels, in key events of cancer cell function such as proliferation, metastasis, autophagy and angiogenesis, has recently begun to be appreciated. Of particular note are two-pore channels (TPCs), a group of recently identified Ca2+-channels, located within the endolysosomal system. TPC2 has recently emerged as an intracellular ion channel of significant pathophysiological relevance, specifically in cancer, and interest in its role as an anti-cancer drug target has begun to be explored. Herein, an overview of the cancer-related functions of TPC2 and a discussion of its potential as a target for therapeutic intervention, including a summary of clinical trials examining the TPC2 inhibitors, naringenin, tetrandrine, and verapamil for the treatment of various cancers is provided.
- Subject
- two-pore channel 2; TPCN2; tetrandrine; naringenin; cancer; anti-cancer drugs; verapamil; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1485770
- Identifier
- uon:51695
- Identifier
- ISSN:2692-3114
- Rights
- x
- Language
- eng
- Reviewed
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