- Title
- Interpersonal Trauma and Depression Severity Among Individuals With Bipolar Disorder: Findings From the Prechter Longitudinal Study of Bipolar Disorder
- Creator
- Wrobel, Anna L.; Russell, Samantha E.; Ehrlich, Tobin J.; Marshall, David F.; Berk, Michael; McInnis, Melvin G.; Jayasinghe, Anuradhi; Lotfaliany, Mojtaba; Turner, Alyna; Dean, Olivia M.; Cotton, Sue M.; Diaz-Byrd, Claudia; Yocum, Anastasia K.; Duval, Elizabeth R.
- Relation
- Journal of Clinical Psychiatry Vol. 84, Issue 3, no. 22m14434
- Publisher Link
- http://dx.doi.org/10.4088/JCP.22m14434
- Publisher
- Physicians Postgraduate Press
- Resource Type
- journal article
- Date
- 2023
- Description
- Background: Experiences of interpersonal trauma, both in childhood and in adulthood, can affect the trajectory of bipolar disorder (BD). However, the degree to which childhood and/or adult trauma impacts the longitudinal trajectory of depression severity among individuals with BD actively receiving treatment remains unclear. Methods: The effects of childhood trauma (Childhood Trauma Questionnaire) and adult trauma (Life Events Checklist) on depression severity (Hamilton Depression Rating Scale) were investigated in a treatment-receiving subsample with BD (DSM-IV) of the Prechter Longitudinal Study of Bipolar Disorder (2005-present). A mixed-effects linear regression model was used to assess the trajectory of depression severity over 4 years. Results: Depression severity was evaluated in 360 participants, of whom 267 (74.8%) reported a history of interpersonal trauma. A history of childhood trauma alone (n = 110) and childhood and adult trauma combined (n = 108)-but not adult trauma alone (n = 49) -were associated with greater depression severity at the 2-year and 6-year follow-up assessments. However, the trajectory of depression severity (ie, change over time) was similar between participants with a history of childhood trauma, those with a history of adult trauma, and those with no history of interpersonal trauma. Interestingly, participants with a history of both types of trauma showed more improvement in depression severity (ie, from year 2 to year 4: β = 1.67, P = .019). Conclusions: Despite actively receiving treatment for BD, participants with a history of interpersonal trauma-particularly childhood trauma-presented with more severe depressive symptoms at several follow-up assessments. Hence, interpersonal trauma may represent an essential treatment target.
- Subject
- bipolar disorder; trauma; depression; depression severity
- Identifier
- http://hdl.handle.net/1959.13/1483548
- Identifier
- uon:51126
- Identifier
- ISSN:0160-6689
- Language
- eng
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