- Title
- Mortality risk increased in colonic diverticular disease: a nationwide cohort study
- Creator
- Cameron, Raquel; Walker, Marjorie M.; Thuresson, Marcus; Roelstraete, Bjorn; Sköldberg, Filip; Olén, Ola; Talley, Nicholas J.; Ludvigsson, Jonas F.
- Relation
- Annals of Epidemiology Vol. 76, Issue December 2022, p. 39-49
- Publisher Link
- http://dx.doi.org/10.1016/j.annepidem.2022.10.006
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2022
- Description
- Introduction: There are limited population cohort data on overall and cause-specific mortality in colonic diverticular disease. Objective: To measure overall and cause-specific mortality in colonic diverticular disease, compared to matched reference individuals and siblings. Methods: Population-based cohort study (“the ESPRESSO study”) in Sweden. There were 97,850 cases with a medical diagnosis of diverticular disease (defined by international classification of disease codes) and colorectal histology identified in 1987–2017 from histopathology reports. The mortality risk between individuals with colonic diverticular disease and matched reference individuals (n = 453/634) from the general population was determined. Cox regression models adjusted for comorbidity estimated hazard ratios (HRs) for all-cause mortality. Results: During follow-up, there were 32,959 deaths in individuals with colonic diverticular disease (44/1000 person-years) compared with 127,153 in matched reference individuals (34/1000 person-years), resulting in an HR of 1.27 (95%CI 1.25–1.29). Also compared to siblings, colonic diverticular disease patients were at increased risk of death, HR 1.39 (95%CI 1.33–1.45). Mortality risks were further increased in colonic diverticular disease patients with a colorectal biopsy showing any mucosal inflammation HR 1.36; (95%CI 1.33–1.38), with the most significant increase during the first year after diagnosis HR 2.18; (95%CI 2.05–2.32). Conclusions: Mortality in colonic diverticular disease is increased over reference individuals in the general population. The presence of mucosal inflammation on colorectal biopsies is a predictor of increased risk of mortality.
- Subject
- diverticulosis; diverticulitis; diverticular disease; mortality; inflammation; gastroenterology; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1482069
- Identifier
- uon:50849
- Identifier
- ISSN:1047-2797
- Rights
- © 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
- Reviewed
- Hits: 1088
- Visitors: 1152
- Downloads: 73
Collections
Goal 3: Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 1 MB | Adobe Acrobat PDF | View Details Download |