- Title
- A current perspective on snake venom composition and constituent protein families
- Creator
- Tasoulis, Theo; Isbister, Geoffrey K.
- Relation
- Archives of Toxicology Vol. 97, Issue 1, p. 133-153
- Publisher Link
- http://dx.doi.org/10.1007/s00204-022-03420-0
- Publisher
- Springer
- Resource Type
- journal article
- Date
- 2023
- Description
- Snake venoms are heterogeneous mixtures of proteins and peptides used for prey subjugation. With modern proteomics there has been a rapid expansion in our knowledge of snake venom composition, resulting in the venom proteomes of 30% of vipers and 17% of elapids being characterised. From the reasonably complete proteomic coverage of front-fanged snake venom composition (179 species-68 species of elapids and 111 species of vipers), the venoms of vipers and elapids contained 42 different protein families, although 18 were only reported in < 5% of snake species. Based on the mean abundance and occurrence of the 42 protein families, they can be classified into 4 dominant, 6 secondary, 14 minor, and 18 rare protein families. The dominant, secondary and minor categories account for 96% on average of a snake's venom composition. The four dominant protein families are: phospholipase A2 (PLA2), snake venom metalloprotease (SVMP), three-finger toxins (3FTx), and snake venom serine protease (SVSP). The six secondary protein families are: L-amino acid oxidase (LAAO), cysteine-rich secretory protein (CRiSP), C-type lectins (CTL), disintegrins (DIS), kunitz peptides (KUN), and natriuretic peptides (NP). Venom variation occurs at all taxonomic levels, including within populations. The reasons for venom variation are complex, as variation is not always associated with geographical variation in diet. The four dominant protein families appear to be the most important toxin families in human envenomation, being responsible for coagulopathy, neurotoxicity, myotoxicity and cytotoxicity. Proteomic techniques can be used to investigate the toxicological profile of a snake venom and hence identify key protein families for antivenom immunorecognition.
- Subject
- snake venom; snake venom proteomes; snake venom protein families; snake toxins; PLA2; three-finger toxins
- Identifier
- http://hdl.handle.net/1959.13/1479795
- Identifier
- uon:50379
- Identifier
- ISSN:0340-5761
- Language
- eng
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