- Hypofractionated versus standard fractionation radiotherapy in early glottic cancer: a retrospective review
- Gupta, Sanjiv A.; Wratten, Chris R.; Ludbrook, Jane J.; O'Brien, Peter C.; Kumar, Mahesh B.; Denham, James W.
- Asia-Pacific Journal of Clinical Oncology Vol. 4, Issue 4, p. 239-243
- Publisher Link
- Blackwell Publishing Asia
- Resource Type
- journal article
- Aim: This retrospective review was conducted to compare outcomes using different fractionation schedules for early stage glottic cancer treated with radiotherapy between 1991 and 2003. Methods: The records of 87 patients with either T1 or T2 squamous cell carcinomas of the glottic larynx were analysed, dividing the patients into those treated with a hypofractionated schedule, mostly 51 Gy/16# (<53 Gy) and standard fractionation, minimum 60 Gy/30# in 2 Gy fractions. The median follow up was 4 years and 7 months. Results: Local control at 5 years was 81% with standard fractionation vs 93% in the hypofractionated group (P = 0.1). Laryngectomy free survival at 5 years was 78% with standard fractionation versus 95% in the hypofractionated arm (P = 0.017). Overall survival at 5 years was 65% with standard fractionation versus 74% in the hypofractionated arm (P = 0.55). Conclusion: In early stage glottic cancer, a hypofractionated course of radiotherapy has been shown to be a safe and possibly more effective treatment compared with standard fractionation.
- glottic cancer; hypofractionated; local control; radiotherapy
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