- Title
- Regional changes with global brain hypometabolism indicates a physiological triage phenomenon and can explain shared pathophysiological events in Alzheimer’s & small vessel diseases and delirium
- Creator
- Gupta, Sandeep K.; Rutherford, Natalie; Dolja-Gore, Xenia; Watson, Tahne; Nair, Balakrishnan R.
- Relation
- American journal of nuclear medicine and molecular imaging Vol. 11, Issue 6, p. 492-506
- Relation
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727878/
- Publisher
- E-Century Publishing Corporation
- Resource Type
- journal article
- Date
- 2021
- Description
- While reduced global brain metabolism is known in aging, Alzheimer's disease (AD), small vessel disease (SVD) and delirium, explanation of regional brain metabolic (rBM) changes is a challenge. We hypothesized that this may be explained by "triage phenomenon", to preserve metabolic supply to vital brain areas. We studied changes in rBM in 69 patients with at least 5% decline in global brain metabolism during active lymphoma. There was significant decline in the rBM of the inferior parietal, precuneus, superior parietal, lateral occipital, primary visual cortices (P<0.001) and in the right lateral prefrontal cortex (P=0.01). Some areas showed no change; multiple areas had significantly increased rBM (e.g. medial prefrontal, anterior cingulate, pons, cerebellum and mesial temporal cortices; P<0.001). We conclude the existence of a physiological triage phenomenon and argue a new hypothetical model to explain the shared events in the pathophysiology of aging, AD, SVD and delirium.
- Subject
- Alzheimer’s disease; delirium; dementia; aging; small vessel disease; cerebral metabolism
- Identifier
- http://hdl.handle.net/1959.13/1478002
- Identifier
- uon:50078
- Identifier
- ISSN:2160-8407
- Language
- eng
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