- Title
- Reply: Vaginal progesterone treatment and circulating progesterone levels—An association yet to be determined
- Creator
- Johnsson, Vilma L.; Smith, Roger; Rode, Line
- Relation
- Acta Obstetricia et Gynecologica Scandinavica Vol. 98, Issue 3, p. 398-38
- Publisher Link
- http://dx.doi.org/10.1111/aogs.13491
- Publisher
- John Wiley & Sons
- Resource Type
- journal article
- Date
- 2018
- Description
- This is a reply to the comment by Levin & Rottenstreich1 on our recently published study Plasma progesterone, estradiol, and unconjugated estriol concentrations in twin pregnancies: Relation to cervical length and preterm delivery.2 We would like to thank the authors for showing interest in our research. Our study examined the association between plasma hormone concentrations, cervical length and preterm delivery in twin pregnancies. We also investigated the effect of vaginal progesterone treatment on plasma hormone concentrations. The main conclusion of our study was that progesterone, estradiol and unconjugated estriol concentrations are associated with neither cervical length nor preterm delivery, and we did not find evidence of increased plasma hormone concentrations after 4-8 weeks of treatment with progesterone compared with the placebo group in this substudy of a double-blinded, randomized placebo-controlled trial investigating the effect of vaginal progesterone for prevention of preterm delivery in twin pregnancies.
- Subject
- progesterone treatment; estriol; plasma hormone concentrations; preterm delivery; twin pregnancies
- Identifier
- http://hdl.handle.net/1959.13/1476860
- Identifier
- uon:49872
- Identifier
- ISSN:1600-0412
- Language
- eng
- Reviewed
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