- Title
- Laparoscopy in emergency: Why not? Advantages of laparoscopy in major emergency: A review
- Creator
- Ietto, Giuseppe; Amico, Francesco; Pettinato, Giuseppe; Iori, Valentina; Carcano, Giulio
- Relation
- Life Vol. 11, Issue 9, no. 917
- Publisher Link
- http://dx.doi.org/10.3390/life11090917
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2021
- Description
- A laparoscopic approach is suggested with the highest grade of recommendation for acute cholecystitis, perforated gastroduodenal ulcers, acute appendicitis, gynaecological disorders, and non-specific abdominal pain (NSAP). To date, the main qualities of laparoscopy for these acute surgical scenarios are clearly stated: quicker surgery, faster recovery and shorter hospital stay. For the remaining surgical emergencies, as well as for abdominal trauma, the role of laparoscopy is still a matter of debate. Patients might benefit from a laparoscopic approach only if performed by experienced teams and surgeons which guarantee a high standard of care. More precisely, laparoscopy can limit damage to the tissue and could be effective for the reduction of the overall amount of cell debris, which is a result of the intensity with which the immune system reacts to the injury and the following symptomatology. In fact, these fragments act as damage-associated molecular patterns (DAMPs). DAMPs, as well as pathogen associated molecular patterns (PAMPs), are recognised by both surface and intracellular receptors of the immune cells and activate the cascade which, in critically ill surgical patients, is responsible for a deranged response. This may result in the development of progressive and multiple organ dysfunctions, manifesting with acute respiratory distress syndrome (ARDS), coagulopathy, liver dysfunction and renal failure. In conclusion, none of the emergency surgical scenarios preclude laparoscopy, provided that the surgical tactic could ensure sufficient cleaning of the abdomen in addition to resolving the initial tissue damage caused by the “trauma”.
- Subject
- laparoscopy; emergency surgery; trauma; immune system; damage-associated molecular patterns (DAMPs); multiple organ dysfunction
- Identifier
- http://hdl.handle.net/1959.13/1476280
- Identifier
- uon:49788
- Identifier
- ISSN:2075-1729
- Rights
- © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
- Reviewed
- Hits: 898
- Visitors: 980
- Downloads: 89
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 347 KB | Adobe Acrobat PDF | View Details Download |