- Title
- Detection of early diabetic retinopathy using visual electrophysiological tests
- Creator
- Dahanayake, Padmini; Dassanayake, Tharaka L.; Pathirage, Manoji; Senanayake, Saman; Sedgwick, Mike; Weerasinghe, Vajira
- Relation
- International Journal of Diabetes in Developing Countries Vol. 41, Issue 3, p. 484-490
- Publisher Link
- http://dx.doi.org/10.1007/s13410-020-00916-2
- Publisher
- Springer
- Resource Type
- journal article
- Date
- 2021
- Description
- Background: Detection of functional impairment of vision in pre-clinical stages helps early identification of diabetic retinopathy. We aimed to determine the functional integrity of retina and post retinal pathways using electro-oculography (EOG), pattern electroretinography (PERG) and pattern-reversal visual evoked potentials (PR-VEP) in newly diagnosed diabetic patients who have not developed fundoscopic features of diabetic retinopathy. Methods: Twenty-five adults with newly diagnosed diabetes mellitus without fundoscopic evidence of retinopathy and a control group of healthy adults were subjected to visual electrophysiological assessment. Retinal pigment epithelium (RPE)-photoreceptor interaction, photoreceptors and ganglion cells of the macula and post retinal pathways were assessed by EOG, PERG and PR-VEP, respectively. Results: Fourteen of the 25 diabetic patients, i.e. 56% (95% confidence intervals 34.9%, 75.6%), had LP:DT (light peak to dark trough) ratio less than 1.7, to the cut-off defined by the International Society for Clinical Electrophysiology of Vision (ISCEV). All control group subjects had LP:DT ratios above 1.7. The median LP:DT ratio in diabetic group (1.62 ± IQR 0.27) was significantly lower than that of the controls (1.8 ± IQR 0.21). Four patients had prolonged PR-VEP P100 latencies, and seven had prolonged PERG P50 latencies as per the ISCEV cut-offs, whereas none of the control group had abnormal PERG or PR-VEP measures. Conclusion: With a limited sample, we found that 56% of newly diagnosed diabetic patients with normal fundoscopy had defective RPE-photoreceptor interaction. Further studies are needed to obtain more precise point estimates of these EOG abnormalities, and to determine the conversion rates into more advanced stages of diabetic retinopathy.
- Subject
- early diabetes; electro-oculography; pattern electroretinography; pattern-reversal visual evoked potentials; SDG 3; SDG 17; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1474639
- Identifier
- uon:49330
- Identifier
- ISSN:0973-3930
- Language
- eng
- Reviewed
- Hits: 840
- Visitors: 836
- Downloads: 0
| Thumbnail | File | Description | Size | Format |
|---|