- Title
- Role of smoking in functional dyspepsia and irritable bowel syndrome: three random population-based studies
- Creator
- Talley, Nicholas J.; Powell, Nicholas; Agréus, Lars; Andreasson, Anna; Walker, Marjorie M.; Jones, Mike P.; Ronkainen, Jukka; Forsberg, Anna; Kjellstrom, Lars; Hellström, Per M.; Aro, Pertti; Wallner, Bengt
- Relation
- Alimentary Pharmacology & Therapeutics Vol. 54, Issue 1, p. 32-42
- Publisher Link
- http://dx.doi.org/10.1111/apt.16372
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2021
- Description
- Background: It is uncertain if functional dyspepsia (FD) or irritable bowel syndrome (IBS) are linked to smoking, and smoking cessation is not part of the routine advice provided to these patients. Aim: To assess if smoking is an independent risk factor for FD and IBS. Methods: Three population-based endoscopy studies in Sweden with 2560 community individuals in total (mean age 51.5 years, 46% male). IBS (14.9%), FD (33.5%), and associated symptoms were assessed using the validated abdominal symptom questionnaire, and smoking (17.9%) was obtained from standardised questions during a clinic visit. The effect of smoking on symptom status was analysed in an individual person data meta-analysis using mixed effect logistic regression, adjusted for snuffing, age and sex. Results: Individuals smoking cigarettes reported significantly higher odds of postprandial distress syndrome (FD-PDS) (OR 10-19 cig/day = 1.42, 95% CI 1.04-1.98 P = 0.027, OR ≥20 cig/day = 2.16, 95% CI 1.38-3.38, P = 0.001) but not epigastric pain. Individuals smoking 20 or more cigarettes per day reported significantly higher odds of IBS-diarrhoea (OR = 2.40, 95% CI 1.12-5.16, P = 0.025), diarrhoea (OR = 2.01, 95%CI 1.28-3.16, P = 0.003), urgency (OR = 2.21, 95%CI 1.41-3.47, P = 0.001) and flatus (OR = 1.77, 95%CI 1.14-2.76, P = 0.012) than non-smokers. Smoking was not associated with IBS-constipation or IBS-mixed. Conclusion: Smoking is an important environmental risk factor for postprandial distress syndrome, the most common FD subgroup, with over a twofold increased odds of PDS in heavy smokers. The role of smoking in IBS-diarrhoea, but not constipation, is also likely important.
- Subject
- diarrhea; dyspepsia; irritable bowel syndrome (IBS); smoking
- Identifier
- http://hdl.handle.net/1959.13/1473390
- Identifier
- uon:49006
- Identifier
- ISSN:0269-2813
- Language
- eng
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