Serum magnesium and calcium levels in relation to ischemic stroke: mendelian randomization study

Larsson, Susanna C.; Traylor, Matthew; Okada, Y; Levi, Christopher R.; Mishra, A; Rutten-Jacobs, L; Giese, AK; Van Der Laan, SW; Gretarsdottir, S; Anderson, CD; Chong, M; Adams, HHH; Ago, T; Burgess, Stephen; Almgren, P; Amouyel, P; Ay, H; Bartz, RM; Benavente, OR; Bevan, S; Brown, RD; Butterworth, AS; Carrera, C; Carty, CL; Boncoraglio, Giorgio B.; Chasman, DI; Chen, WM; Cole, JW; Correa, A; Cotlarciuc, I; Cruchaga, C; Danesh, J; De Bakker, PIW; Destefano, AL; Hoed, MD; Jern, Christina; Duan, Q; Engelter, ST; Falcone, GJ; Gottesman, RF; Grewal, RP; Gudnason, V; Gustafsson, S; Haessler, J; Harris, TB; Hassan, A; Michaëlsson, Karl; Havulinna, AS; Heckbert, SR; Holliday, Elizabeth G.; Howard, G; Hsu, FC; Hyacinth, HI; Ikram, MA; Ingelsson, E; Irvin, MR; Jian, X; Markus, Hugh S.; Jiménez-Conde, J; Johnson, JA; Jukema, JW; Kanai, M; Keene, KL; Kissela, BM; Kleindorfer, DO; Kooperberg, C; Kubo, M; Lange, LA; Malik, R; Langefeld, CD; Langenberg, C; Launer, LJ; Lee, JM; Lemmens, R; Leys, D; Lewis, CM; Lin, WY; Lindgren, AG; Lorentzen, E; Chauhan, G; Magnusson, PK; Maguire, J; Manichaikul, A; McArdle, PF; Meschia, JF; Mitchell, BD; Mosley, TH; Nalls, MA; Ninomiya, T; O'Donnell, MJ; Sargurupremraj, M; Psaty, BM; Pulit, SL; Rannikmäe, K; Reiner, AP; Rexrode, KM; Rice, K; Rich, SS; Ridker, PM; Rost, NS; Rothwell, PM

Title: Serum magnesium and calcium levels in relation to ischemic stroke: mendelian randomization study
Creator: Larsson, Susanna C.; Traylor, Matthew; Okada, Y; Levi, Christopher R.; Mishra, A; Rutten-Jacobs, L; Giese, AK; Van Der Laan, SW; Gretarsdottir, S; Anderson, CD; Chong, M; Adams, HHH; Ago, T; Burgess, Stephen; Almgren, P; Amouyel, P; Ay, H; Bartz, RM; Benavente, OR; Bevan, S; Brown, RD; Butterworth, AS; Carrera, C; Carty, CL; Boncoraglio, Giorgio B.; Chasman, DI; Chen, WM; Cole, JW; Correa, A; Cotlarciuc, I; Cruchaga, C; Danesh, J; De Bakker, PIW; Destefano, AL; Hoed, MD; Jern, Christina; Duan, Q; Engelter, ST; Falcone, GJ; Gottesman, RF; Grewal, RP; Gudnason, V; Gustafsson, S; Haessler, J; Harris, TB; Hassan, A; Michaëlsson, Karl; Havulinna, AS; Heckbert, SR; Holliday, Elizabeth G.; Howard, G; Hsu, FC; Hyacinth, HI; Ikram, MA; Ingelsson, E; Irvin, MR; Jian, X; Markus, Hugh S.; Jiménez-Conde, J; Johnson, JA; Jukema, JW; Kanai, M; Keene, KL; Kissela, BM; Kleindorfer, DO; Kooperberg, C; Kubo, M; Lange, LA; Malik, R; Langefeld, CD; Langenberg, C; Launer, LJ; Lee, JM; Lemmens, R; Leys, D; Lewis, CM; Lin, WY; Lindgren, AG; Lorentzen, E; Chauhan, G; Magnusson, PK; Maguire, J; Manichaikul, A; McArdle, PF; Meschia, JF; Mitchell, BD; Mosley, TH; Nalls, MA; Ninomiya, T; O'Donnell, MJ; Sargurupremraj, M; Psaty, BM; Pulit, SL; Rannikmäe, K; Reiner, AP; Rexrode, KM; Rice, K; Rich, SS; Ridker, PM; Rost, NS; Rothwell, PM
Relation: Neurology Vol. 92, Issue 9, p. E944-E950
Publisher Link: http://dx.doi.org/10.1212/WNL.0000000000007001
Publisher: Lippincott Williams & Wilkins
Resource Type: journal article
Date: 2019
Description: Objective: To determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach. Methods: Analyses were conducted using summary statistics data for 13 single-nucleotide polymorphisms robustly associated with serum magnesium (n = 6) or serum calcium (n = 7) concentrations. The corresponding data for ischemic stroke were obtained from the MEGASTROKE consortium (34,217 cases and 404,630 noncases). Results: In standard mendelian randomization analysis, the odds ratios for each 0.1 mmol/L (about 1 SD) increase in genetically predicted serum magnesium concentrations were 0.78 (95% confidence interval [CI] 0.69–0.89; p = 1.3 x 10⁻⁴) for all ischemic stroke, 0.63 (95% CI 0.50–0.80; p = 1.6 x 10⁻⁴) for cardioembolic stroke, and 0.60 (95% CI 0.44–0.82; p = 0.001) for large artery stroke; there was no association with small vessel stroke (odds ratio 0.90, 95% CI 0.67–1.20; p = 0.46). Only the association with cardioembolic stroke was robust in sensitivity analyses. There was no association of genetically predicted serum calcium concentrations with all ischemic stroke (per 0.5 mg/dL [about 1 SD] increase in serum calcium: odds ratio 1.03, 95% CI 0.88–1.21) or with any subtype. Conclusions: This study found that genetically higher serum magnesium concentrations are associated with a reduced risk of cardioembolic stroke but found no significant association of genetically higher serum calcium concentrations with any ischemic stroke subtype.
Subject: cerebrovascular disease/stroke; association studies in genetics; risk factors in epidemiology; stroke prevention; SDG 3; Sustainable Development Goals
Identifier: http://hdl.handle.net/1959.13/1470623
Identifier: uon:48519
Identifier: ISSN:0028-3878
Rights: Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/legalcode
Language: eng
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