- Title
- Low oxygen post conditioning as an efficient non-pharmacological strategy to promote motor function after stroke
- Creator
- Pietrogrande, Giovanni; Zalewska, Katarzyna; Zhao, Zidan; Johnson, Sarah J.; Nilsson, Michael; Walker, Frederick R.
- Relation
- Translational Stroke Research Vol. 10, p. 402-412
- Publisher Link
- http://dx.doi.org/10.1007/s12975-018-0656-5
- Publisher
- Springer
- Resource Type
- journal article
- Date
- 2019
- Description
- Low oxygen post conditioning (LOPC) has shown promising results in terms of neuroprotection after stroke, but the effects on motor function have not been considered. Cortical stroke targeting the motor and sensory cortex was induced by photothrombotic occlusion and after 48 h allocated to LOPC (11% O2) for 2 weeks. Motor impairment was assessed using the cylinder and grid walk tests during the exposure period and for two further weeks upon completion of the intervention. Neuroprotection was evaluated by histological and molecular analysis at two time points. Two weeks of LOPC was sufficient to significantly reduce motor deficits and tissue loss after stroke. This functional improvement was associated with increased capillary density, enhanced levels of BDNF, decreased neuronal loss and decreased microglia activation. These improvements, in most instances, were maintained up to 2 weeks after the end of the treatment. To our knowledge, this is the first study to demonstrate that LOPC induces a persistent improvement in motor function and neuroprotection after stroke, and in doing so provides evidence to support a case for considering taking LOPC forward to early stage clinical research.
- Subject
- stroke; motor function; neuroprotection; BDNF; hypoxia; angiogenesis; inflammation
- Identifier
- http://hdl.handle.net/1959.13/1468942
- Identifier
- uon:48127
- Identifier
- ISSN:1868-4483
- Rights
- © The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Language
- eng
- Full Text
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