Astrocyte activation and reactive gliosis - a new target in stroke?

Title: Astrocyte activation and reactive gliosis - a new target in stroke?
Creator: Pekny, Milos; Wilhelmsson, Ulrika; Tatlisumak, Turgut; Pekna, Marcela
Relation: Neuroscience Letters Vol. 689, p. 45-55
Publisher Link: http://dx.doi.org/10.1016/j.neulet.2018.07.021
Publisher: Elsevier
Resource Type: journal article
Date: 2019
Description: Stroke is an acute insult to the central nervous system (CNS) that triggers a sequence of responses in the acute, subacute as well as later stages, with prominent involvement of astrocytes. Astrocyte activation and reactive gliosis in the acute stage of stroke limit the tissue damage and contribute to the restoration of homeostasis. Astrocytes also control many aspects of neural plasticity that is the basis for functional recovery. Here, we discuss the concept of intermediate filaments (nanofilaments) and the complement system as two handles on the astrocyte responses to injury that both present attractive opportunities for novel treatment strategies modulating astrocyte functions and reactive gliosis.
Subject: astrocytes; reactive gliosis; intermediate filaments (nanofilaments); vimentin; brian ischemia; perinatal asphyxia; SDG 3; Sustainable Development Goals
Identifier: http://hdl.handle.net/1959.13/1468838
Identifier: uon:48116
Identifier: ISSN:0304-3940
Language: eng
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