- Title
- Establishing and maintaining fertility: the importance of cell cycle arrest
- Creator
- Frost, Emily R.; Taylor, Güneş; Baker, Mark A.; Lovell-Badge, Robin; Sutherland, Jessie M.
- Relation
- Genes & Development Vol. 35, Issue 9-10, p. 619-634
- Publisher Link
- http://dx.doi.org/10.1101/gad.348151.120
- Publisher
- Cold Spring Harbour Press
- Resource Type
- journal article
- Date
- 2021
- Description
- Development of the ovary or testis is required to establish reproductive competence. Gonad development relies on key cell fate decisions that occur early in embryonic development and are actively maintained. During gonad development, both germ cells and somatic cells proliferate extensively, a process facilitated by cell cycle regulation. This review focuses on the Cip/Kip family of cyclin-dependent kinase inhibitors (CKIs) in mouse gonad development. We particularly highlight recent single-cell RNA sequencing studies that show the heterogeneity of cyclin-dependent kinase inhibitors. This diversity highlights new roles for cell cycle inhibitors in controlling and maintaining female fertility.
- Subject
- Cip/Kip; gonad; granulosa; oocyte
- Identifier
- http://hdl.handle.net/1959.13/1468504
- Identifier
- uon:48057
- Identifier
- ISSN:0890-9369
- Rights
- © 2021 Frost et al.; Published by Cold Spring Harbor Laboratory Press. This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.
- Language
- eng
- Full Text
- Reviewed
- Hits: 1827
- Visitors: 1924
- Downloads: 97
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 12 MB | Adobe Acrobat PDF | View Details Download |