- Title
- Tumor neurobiology and the war of nerves in cancer
- Creator
- Faulkner, Sam; Jobling, Phillip; March, Brayden; Jiang, Chen Chen; Hondermarck, Hubert
- Relation
- Cancer Discovery Vol. 9, Issue 6, p. 702-710
- Publisher Link
- http://dx.doi.org/10.1158/2159-8290.CD-18-1398
- Publisher
- American Association for Cancer Research
- Resource Type
- journal article
- Date
- 2019
- Description
- Nerves are emerging regulators of cancer progression. Cancer cells induce the outgrowth of nerves in the tumor microenvironment through the release of neu-rotrophic factors, and in return nerves liberate neurotransmitters that activate cancer growth and dissemination. Although sympathetic nerves drive tumor angiogenesis via the liberation of noradrena-line, sensory and parasympathetic nerves stimulate cancer stem cells. Interestingly, recent evidence indicates that parasympathetic nerves can eventually inhibit tumor progression, suggesting a yin-yang type of regulation of cancer by nerves. From a broader perspective, the question of a higher level of control of cancer development by the central nervous system should be raised. Significance: Nerves are emerging regulators of cancer initiation, progression, and metastasis. Here, we review the evidence to date and explore the basic and clinical ramifications of these findings.
- Subject
- tumor; war of nerves; cancer; nervous system; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1467549
- Identifier
- uon:47842
- Identifier
- ISSN:2159-8274
- Language
- eng
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