- Title
- Post-traumatic stress disorder affects fucose-alpha(1-2)-glycans in the human brain: preliminary findings of neuro deregulation using in vivo two-dimensional neuro MR spectroscopy
- Creator
- Quadrelli, Scott; Tosh, Nathan; Urquhart, Aaron; Trickey, Katie; Tremewan, Rosanna; Galloway, Graham; Rich, Lisa; Lea, Rodney; Malycha, Peter; Mountford, Carolyn
- Relation
- Translational Psychiatry Vol. 9, Issue 1, no. 27
- Publisher Link
- http://dx.doi.org/10.1038/s41398-018-0365-6
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2019
- Description
- Post-traumatic stress disorder (PTSD) is triggered by experiencing terrifying event(s) for which there is currently no objective test for a definitive diagnosis. We report a pilot study where two-dimensional (2D) neuro magnetic resonance spectroscopy (MRS), collected at 3 T in a clinical scanner with a 64-channel head coil, identifies neuro deregulation in the PTSD cohort. The control subjects (n = 10) were compared with PTSD participants with minimal co-morbidities (n = 10). The 2D MRS identified statistically significant increases in the total spectral region containing both free substrate fucose and fucosylated glycans of 31% (P = 0.0013), two of multiple fucosylated glycans (Fuc IV and VI) were elevated by 48% (P = 0.002), and 41% (P = 0.02), respectively, imidazole was increased by 12% (P = 0.002), and lipid saturation was increased by 12.5% (P = 0.009). This is the first evidence of fucosylated glycans, reported in animals to be involved in learning and memory, to be affected in humans with PTSD.
- Subject
- post-traumatic stress disorder (PTSD); human brain; two-dimensional (2D); magnetic resonance spectroscopy (MRS)
- Identifier
- http://hdl.handle.net/1959.13/1467093
- Identifier
- uon:47742
- Identifier
- ISSN:2158-3188
- Language
- eng
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