Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Malik, Rainer; Chauhan, Ganesh; Anderson, Christopher D.; Chong, Michael; Adams, Hieab H. H.; Ago, Tetsuro; Almgren, Peter; Amouyel, Philippe; Ay, Hakan; Bartz, Traci M.; Benavente, Oscar R.; Bevan, Steve; Traylor, Matthew; Holliday, Elizabeth G.; Attia, John; Levi, Christopher R.; Carrera, C; Carty, CL; Chasman, DI; Chen, W-M; Cole, JW; Correa, A; Cotlarciuc, I; Sargurupremraj, Muralidharan; Cruchaga, C; Danesh, J; de Bakker, PIW; DeStefano, AL; Den Hoed, M; Duan, Q; Engelter, ST; Falcone, GJ; Gottesman, RF; Grewal, RP; Okada, Yukinori; Gudnason, V; Gustafsson, S; Haessler, J; Harris, TB; Hassan, A; Havulinna, AS; Heckbert, SR; Holliday, EG; Howard, G; Hsu, F-C; Mishra, Aniket; Hyacinth, HI; Ikram, MA; Ingelsson, E; Irvin, MR; Jian, X; Jiménez-Conde, J; Johnson, JA; Jukema, JW; Kanai, M; Keene, KL; Rutten-Jacobs, Loes; Kissela, BM; Kleindorfer, DO; Kooperberg, C; Kubo, M; Lange, LA; Langefeld, CD; Langenberg, C; Launer, LJ; Lee, J-M; Lemmens, R; Giese, Anne-Katrin; van der Laan, Sander W.; Gretarsdottir, Solveig

Title: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Creator: Malik, Rainer; Chauhan, Ganesh; Anderson, Christopher D.; Chong, Michael; Adams, Hieab H. H.; Ago, Tetsuro; Almgren, Peter; Amouyel, Philippe; Ay, Hakan; Bartz, Traci M.; Benavente, Oscar R.; Bevan, Steve; Traylor, Matthew; Holliday, Elizabeth G.; Attia, John; Levi, Christopher R.; Carrera, C; Carty, CL; Chasman, DI; Chen, W-M; Cole, JW; Correa, A; Cotlarciuc, I; Sargurupremraj, Muralidharan; Cruchaga, C; Danesh, J; de Bakker, PIW; DeStefano, AL; Den Hoed, M; Duan, Q; Engelter, ST; Falcone, GJ; Gottesman, RF; Grewal, RP; Okada, Yukinori; Gudnason, V; Gustafsson, S; Haessler, J; Harris, TB; Hassan, A; Havulinna, AS; Heckbert, SR; Holliday, EG; Howard, G; Hsu, F-C; Mishra, Aniket; Hyacinth, HI; Ikram, MA; Ingelsson, E; Irvin, MR; Jian, X; Jiménez-Conde, J; Johnson, JA; Jukema, JW; Kanai, M; Keene, KL; Rutten-Jacobs, Loes; Kissela, BM; Kleindorfer, DO; Kooperberg, C; Kubo, M; Lange, LA; Langefeld, CD; Langenberg, C; Launer, LJ; Lee, J-M; Lemmens, R; Giese, Anne-Katrin; van der Laan, Sander W.; Gretarsdottir, Solveig
Relation: Nature Genetics Vol. 50, p. 524-537
Publisher Link: http://dx.doi.org/10.1038/s41588-018-0058-3
Publisher: Nature Publishing Group
Resource Type: journal article
Date: 2018
Description: Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage-disequilibrium-score regression. Several loci exhibited distinct association and pleiotropy patterns for etiological stroke subtypes. Eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets. Stroke risk loci were significantly enriched in drug targets for antithrombotic therapy.
Subject: genetics; genome-wide association; stroke; stroke subtypes; SDG 3; Sustainable Development Goals
Identifier: http://hdl.handle.net/1959.13/1466809
Identifier: uon:47666
Identifier: ISSN:1061-4036
Language: eng
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