- Title
- Advantages and limitations of current imaging techniques for characterizing liposome morphology
- Creator
- Robson, Annie-Louise; Dastoor, Paul C.; Flynn, Jamie; Palmer, William; Martin, Antony; Smith, Doug W.; Woldu, Ameha; Hua, Susan
- Relation
- Frontiers in Pharmacology Vol. 9, Issue FEB, no. 80
- Publisher Link
- http://dx.doi.org/10.3389/fphar.2018.00080
- Publisher
- Frontiers Research Foundation
- Resource Type
- journal article
- Date
- 2018
- Description
- There are currently a number of imaging techniques available for evaluating the morphology of liposomes and other nanoparticles, with each having its own advantages and disadvantages that should be considered when interpreting data. Controlling and validating the morphology of nanoparticles is of key importance for the effective clinical translation of liposomal formulations. There are a number of physical characteristics of liposomes that determine their in vivo behavior, including size, surface characteristics, lamellarity, and homogeneity. Despite the great importance of the morphology of nanoparticles, it is generally not well-characterized and is difficult to control. Appropriate imaging techniques provide important details regarding the morphological characteristics of nanoparticles, and should be used in conjunction with other methods to assess physicochemical parameters. In this review, we will discuss the advantages and limitations of available imaging techniques used to evaluate liposomal formulations.
- Subject
- lipsomes; microscopy; imaging; nanoparticles; light microscopy; electron mircoscopy; atomic-force mircoscopy
- Identifier
- http://hdl.handle.net/1959.13/1466214
- Identifier
- uon:47474
- Identifier
- ISSN:1663-9812
- Rights
- Copyright © 2018 Robson, Dastoor, Flynn, Palmer, Martin, Smith, Woldu and Hua. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Language
- eng
- Full Text
- Reviewed
- Hits: 692
- Visitors: 713
- Downloads: 27
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 563 KB | Adobe Acrobat PDF | View Details Download |