Alterations in brainstem respiratory centers following peripheral inflammation: A systematic review

Title: Alterations in brainstem respiratory centers following peripheral inflammation: A systematic review
Creator: Hedley, Kateleen E.; Callister, Robert J.; Callister, Robin; Horvat, Jay C.; Tadros, Melissa A.
Relation: Journal of Neuroimmunology Vol. 369, Issue 15 August 2022, no. 577903
Publisher Link: http://dx.doi.org/10.1016/j.jneuroim.2022.577903
Publisher: Elsevier
Resource Type: journal article
Date: 2022
Description: Immune mediators upregulated in peripheral to central immune communication can modulate respiratory function by direct action on brainstem respiratory circuits. In this systematic review we consolidated findings from independent studies examining the relationship between peripheral and neuro- inflammation within brainstem respiratory centres. Microglia and astrocytes modulate brainstem neuroinflammation in response to peripheral immune mediators which then regulates neuronal activity and ultimately respiratory behaviours. Overall, respiratory brainstem nuclei showed increases in several key immune factors, and glia showed an increased response following peripheral inflammation. However, the functional impact of this neuroinflammation remains unclear.
Subject: brainstem; inflammation; respiratory; systematic review
Identifier: http://hdl.handle.net/1959.13/1465836
Identifier: uon:47389
Identifier: ISSN:0165-5728
Language: eng
Reviewed