- Title
- In utero exposure to breast cancer treatment: a population-based perinatal outcome study
- Creator
- Safi, Nadom; Anazodo, Antoinette; Dickinson, Jan E.; Lui, Kei; Wang, Alex Y.; Li, Zhuoyang; Sullivan, Elizabeth A.
- Relation
- British Journal of Cancer Vol. 121, Issue 8, p. 719-721
- Publisher Link
- http://dx.doi.org/10.1038/s41416-019-0563-x
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2019
- Description
- Chemotherapy during a viable pregnancy may be associated with adverse perinatal outcomes. We conducted a prospective cohort study to examine the perinatal outcomes of babies born following in utero exposure to chemotherapy in Australia and New Zealand. Over 18 months we identified 24 births, of >400 g and/or >20-weeks' gestation, to women diagnosed with breast cancer in the first or second trimesters. Eighteen babies were exposed in utero to chemotherapy. Chemotherapy commenced at a median of 20 weeks gestation, for a mean duration of 10 weeks. Twelve exposed infants were born preterm with 11 by induced labour or pre-labour caesarean section. There were no perinatal deaths or congenital malformations. Our findings show that breast cancer diagnosed during mid-pregnancy is often treated with chemotherapy. Other than induced preterm births, there were no serious adverse perinatal outcomes.
- Subject
- chemotherapy; breast cancer; perinatal outcomes; utero exposure; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1462975
- Identifier
- uon:46604
- Identifier
- ISSN:0007-0920
- Language
- eng
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Goal 3: Good Health and Well-Being
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