- Title
- The MIR137 VNTR rs58335419 Is Associated with Cognitive Impairment in Schizophrenia and Altered Cortical Morphology
- Creator
- Mahmoudi, Ebrahim; Atkins, Joshua R.; Quide, Yann; Reay, William R.; Cairns, Heath M.; Fitzsimmons, Chantel; Carr, Vaughan J.; Green, Melissa J.; Cairns, Murray J.
- Relation
- NHMRC.1067137 | 1051672 | 1147644 http://purl.org/au-research/grants/nhmrc/1147644
- Relation
- Schizophrenia Bulletin Vol. 47, Issue 2, p. 495-504
- Publisher Link
- http://dx.doi.org/10.1093/schbul/sbaa123
- Publisher
- Oxford University Press
- Resource Type
- journal article
- Date
- 2021
- Description
- Genome-wide association studies (GWAS) of schizophrenia have strongly implicated a risk locus in close proximity to the gene for miR-137. While there are candidate single-nucleotide polymorphisms (SNPs) with functional implications for the microRNA’s expression encompassed by the common haplotype tagged by rs1625579, there are likely to be others, such as the variable number tandem repeat (VNTR) variant rs58335419, that have no proxy on the SNP genotyping platforms used in GWAS to date. Using whole-genome sequencing data from schizophrenia patients (n = 299) and healthy controls (n = 131), we observed that the MIR137 4-repeats VNTR (VNTR4) variant was enriched in a cognitive deficit subtype of schizophrenia and associated with altered brain morphology, including thicker left inferior temporal gyrus and deeper right postcentral sulcus. These findings suggest that the MIR137 VNTR4 may impact neuroanatomical development that may, in turn, influence the expression of more severe cognitive symptoms in patients with schizophrenia.
- Subject
- MIR137 VNTR; schizophrenia; genome sequencing; neuroanatomy; cognitive deficit
- Identifier
- http://hdl.handle.net/1959.13/1462192
- Identifier
- uon:46407
- Identifier
- ISSN:0586-7614
- Rights
- © The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited.
- Language
- eng
- Full Text
- Reviewed
- Hits: 2063
- Visitors: 2151
- Downloads: 102
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 5 MB | Adobe Acrobat PDF | View Details Download |