- Title
- The lipid-lowering effects of phytosterols and (n-3) polyunsaturated fatty acids are synergistic and complementary in hyperlipidemic men and women
- Creator
- Micallef, Michelle A.; Garg, Manohar L.
- Relation
- Journal of Nutrition Vol. 138, Issue 6, p. 1086-1090
- Relation
- http://jn.nutrition.org/cgi/content/abstract/138/6/1086
- Publisher
- American Institute of Nutrition
- Resource Type
- journal article
- Date
- 2008
- Description
- Fish oils rich in (n-3) long-chain PUFA(LCPUFA) can reduce circulating triglycerides and raise HDL-cholesterol. Phytosterols have been shown to reduce total cholesterol and LDL-cholesterol in normocholesterolemic and hyperlipidemic populations. We investigated the combined effects of phytosterols and (n-3) LCPUFA on plasma lipid profile in hyperlipidemic individuals. This study was a 3-wk randomized, double-blind, placebo-controlled, 2 x 2 factorial trial in 4 parallel groups of 60 hyperlipidemic individuals. Subjects were randomized to receive either sunola oil or 1.4 g/d (n-3) LCPUFA capsules with or without 2 g phytosterols per day while maintaining their habitual diet. The combination of phytosterols and (n-3) LCPUFA reduced plasma total cholesterol by 13.3% (P = 0.001), which differed from (n-3) LCPUFA alone (P<0.001). LDL-cholesterol concentrations followed the same pattern as that of plasma cholesterol with a 12.5% decrease (P = 0.002) in the combination group. The HDL-cholesterol concentration was increased by (n-3) LCPUFA (7.1%; P = 0.01) alone and in combination with phytosterols (8.6%; P = 0.04), whereas phytosterol treatment alone had no effect. Plasma triglyceride concentration was lowered by (n-3) LCPUFA (22.3%; P = 0.004) alone and in combination with phytosterols (25.9%; P = 0.005), whereas phytosterol treatment alone had no effect. In conclusion, the combined supplementation with phytosterols and (n-3) LCPUFA has both synergistic and complementary lipid-lowering effects in hyperlipidemic men and women.
- Subject
- mildly hypercholesterolemic subjects; sterol enriched spread; density lipoprotein cholesterol; primary prevention; serum lipids
- Identifier
- http://hdl.handle.net/1959.13/40634
- Identifier
- uon:4637
- Identifier
- ISSN:0022-3166
- Language
- eng
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