Protein-protein interactions as antibiotic targets: a medicinal chemistry perspective

Title: Protein-protein interactions as antibiotic targets: a medicinal chemistry perspective
Creator: Cossar, Peter J.; Lewis, Peter J.; McCluskey, Adam
Relation: Medicinal Research Reviews Vol. 40, Issue 2, p. 469-494
Publisher Link: http://dx.doi.org/10.1002/med.21519
Publisher: John Wiley & Sons
Resource Type: journal article
Date: 2020
Description: There are 27 small molecule protein-protein interaction (PPI) modulators in Phase I, II, and III clinical trials targeting cancer, viruses, autoimmune disorders, and as immune suppression agents. Targeting PPIs as an antibiotic drug discovery strategy remains in relative infancy by comparison. However, a number of molecules are in development which target PPI within the replisome, divisome, transcriptome, and translatome are showing significant promise at the medicinal chemistry stage of drug development. Hence, the success of future PPI agents as antibiotics will build upon the techniques and design strategies of these molecules.
Subject: antibacterial; antibiotic; protein-protein interaction (PPI); medicinal chemistry; SDG 3; Sustainable Development Goals
Identifier: http://hdl.handle.net/1959.13/1461493
Identifier: uon:46213
Identifier: ISSN:0198-6325
Language: eng
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