- Title
- Laryngeal Dysfunction in Severe Asthma: A Cross-Sectional Observational Study
- Creator
- Vertigan, Anne E.; Kapela, Sarah L.; Gibson, Peter G.
- Relation
- Journal of Allergy and Clinical Immunology: In Practice Vol. 9, Issue 2, p. 897-905
- Publisher Link
- http://dx.doi.org/10.1016/j.jaip.2020.09.034
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2021
- Description
- Background: Laryngeal disorders can contribute to disease burden in severe asthma yet the nature of laryngeal disorders in severe asthma is poorly understood. Objective: The aim of this study was to examine laryngeal function in patients with severe asthma. Method: A cross-sectional observational study involving 97 participants compared laryngeal function in patients with severe asthma (n = 53) with patients with laryngeal disorders of vocal cord dysfunction/inducible laryngeal obstruction (n = 16) and muscle tension dysphonia (n = 14), and with healthy controls (n = 13). A pre-post pilot study of speech pathology intervention for laryngeal symptoms was then provided to 11 participants with severe asthma and laryngeal dysfunction. Results: Laryngeal dysfunction was common in severe asthma. The majority of participants with severe asthma (87%) had laryngeal dysfunction, which affected respiration, phonation, or both. Three distinct patterns of laryngeal dysfunction in severe asthma were identified: (1) phonatory laryngeal dysfunction, (2) respiratory laryngeal dysfunction, and (3) combined laryngeal dysfunction. Laryngeal hypersensitivity and impaired voice measures were common in severe asthma. Patient-reported outcome measures improved after therapy, and laryngeal dysfunction improved in 7 (64%) participants. Conclusion: Laryngeal dysfunction affects respiration and phonation in severe asthma. It requires identification and treatment to minimize its impact on asthma symptoms.
- Subject
- asthma; Inducible laryngeal obstruction; paradoxical vocal fold movement; vocal cord dysfunction; dysphonia; severe asthma;; laryngeal dysfunction; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1461108
- Identifier
- uon:46108
- Identifier
- ISSN:2213-2198
- Language
- eng
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