- Title
- When a slice is not enough! Comparison of whole-brain versus standard limited-slice perfusion computed tomography in patients with severe traumatic brain injury
- Creator
- Cooper, Shannon; Bendinelli, Cino; Bivard, Andrew; Parsons, Mark; Balogh, Zsolt J.
- Relation
- Journal of Clinical Medicine Vol. 8, Issue 5, no. 701
- Publisher Link
- http://dx.doi.org/10.3390/jcm8050701
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2019
- Description
- Introduction: Cerebral perfusion computed tomography (PCT) provides crucial information in acute stroke and has an increasing role in traumatic brain injury (TBI) management. Most studies on TBI patients utilize 64-slice scanners, which are limited to four brain slices (limited-brain PCT, LBPCT). Newer 320-slice scanners depict the whole brain perfusion status (WBPCT). We aimed to identify the additional information gained with WBPCT when compared to LBPCT. Patients and methods: Forty-nine patients with severe TBI were investigated within 48 h from admission with WBPCT. Findings from LBPCT were compared with findings from WBPCT. Results: A perfusion abnormality was identified in 39 (80%) and 37 (76%) patients by WBPCT and LBPCT, respectively (p = 0.8). There were 90 and 68 perfusion abnormalities identified by WBPCT and LBPCT, respectively (p < 0.001). In the 39 patients with a perfusion abnormality detected by WBPCT, 15 (38%) had further perfusion abnormalities outside the LBPCT area of coverage. Thirty-six (92%) patients had a larger perfusion abnormality upon WBPCT compared with LBPCT. Additional information gained showed some statistically significant correlation with clinical outcome. Conclusions: In severe TBI patients, WBPCT provides extra information compared to LBPC. The limitations of LBPCT should be considered when evaluating studies reporting on PCT findings and their association with outcomes.
- Subject
- severe traumatic brain injury; perfusion computed tomography; PCT; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1460784
- Identifier
- uon:46050
- Identifier
- ISSN:2077-0383
- Rights
- © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
- Reviewed
- Hits: 1750
- Visitors: 1866
- Downloads: 119
Collections
Goal 3: Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 635 KB | Adobe Acrobat PDF | View Details Download |