The Low-Dimensional Neural Architecture of Cognitive Complexity Is Related to Activity in Medial Thalamic Nuclei

Title: The Low-Dimensional Neural Architecture of Cognitive Complexity Is Related to Activity in Medial Thalamic Nuclei
Creator: Shine, James M.; Hearne, Luke J.; Breakspear, Michael; Hwang, Kai; Müller, Eli J.; Sporns, Olaf; Poldrack, Russell A.; Mattingley, Jason B.; Cocchi, Luca
Relation: Neuron Vol. 104, Issue 5, p. 849-855.e3
Publisher Link: http://dx.doi.org/10.1016/j.neuron.2019.09.002
Publisher: Cell Press
Resource Type: journal article
Date: 2019
Description: Cognitive activity emerges from large-scale neuronal dynamics that are constrained to a low-dimensional manifold. How this low-dimensional manifold scales with cognitive complexity, and which brain regions regulate this process, are not well understood. We addressed this issue by analyzing sub-second high-field fMRI data acquired during performance of a task that systematically varied the complexity of cognitive reasoning. We show that task performance reconfigures the low-dimensional manifold and that deviations from these patterns relate to performance errors. We further demonstrate that individual differences in thalamic activity relate to reconfigurations of the low-dimensional architecture during task engagement.
Subject: cognitive complexity; thalamus; low-dimensionality; state-space; fMRI
Identifier: http://hdl.handle.net/1959.13/1460278
Identifier: uon:45910
Identifier: ISSN:0896-6273
Language: eng
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