- Title
- The Low-Dimensional Neural Architecture of Cognitive Complexity Is Related to Activity in Medial Thalamic Nuclei
- Creator
- Shine, James M.; Hearne, Luke J.; Breakspear, Michael; Hwang, Kai; Müller, Eli J.; Sporns, Olaf; Poldrack, Russell A.; Mattingley, Jason B.; Cocchi, Luca
- Relation
- Neuron Vol. 104, Issue 5, p. 849-855.e3
- Publisher Link
- http://dx.doi.org/10.1016/j.neuron.2019.09.002
- Publisher
- Cell Press
- Resource Type
- journal article
- Date
- 2019
- Description
- Cognitive activity emerges from large-scale neuronal dynamics that are constrained to a low-dimensional manifold. How this low-dimensional manifold scales with cognitive complexity, and which brain regions regulate this process, are not well understood. We addressed this issue by analyzing sub-second high-field fMRI data acquired during performance of a task that systematically varied the complexity of cognitive reasoning. We show that task performance reconfigures the low-dimensional manifold and that deviations from these patterns relate to performance errors. We further demonstrate that individual differences in thalamic activity relate to reconfigurations of the low-dimensional architecture during task engagement.
- Subject
- cognitive complexity; thalamus; low-dimensionality; state-space; fMRI
- Identifier
- http://hdl.handle.net/1959.13/1460278
- Identifier
- uon:45910
- Identifier
- ISSN:0896-6273
- Language
- eng
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