- Title
- Oxidative damage to sperm DNA: attack and defense
- Creator
- Drevet, Joel R.; Aitken, R. J.
- Relation
- Genetic Damage in Human Spermatozoa p. 107-117
- Relation
- Advances in Experimental Medicine and Biology 1166
- Publisher Link
- http://dx.doi.org/10.1007/978-3-030-21664-1_7
- Publisher
- Springer Cham
- Resource Type
- book chapter
- Date
- 2019
- Description
- Due to its particular “silent” metabolic state, without transcription or translation, and a low level of cytosolic protective activities, mature sperm is a cellular type of aerobic organisms particularly at risk of oxidative damage. Despite the efforts of the male genital tract to treat this problem, a subcellular compartment of the sperm, the nucleus, and consequently, the paternal DNA cannot be effectively protected. There is an accumulation of evidence that oxidative damage to sperm DNA is quite common in male infertilities/subfertilities with potential harmful impacts on reproductive success, including the transgenerational inheritance of a paternal chromosomal lot carrying mutations.
- Subject
- reactive oxygen species; male infertility; lipid peroxidation; oxidative DNA damage; DNA repair
- Identifier
- http://hdl.handle.net/1959.13/1459632
- Identifier
- uon:45727
- Identifier
- ISBN:9783030216634
- Language
- eng
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