- Title
- The interactions between genetics and early childhood nutrition influence adult cardiometabolic risk factors
- Creator
- Wang, Carol A.; Attia, John R.; Lye, Stephen J.; Oddy, Wendy H.; Beilin, Lawrence; Mori, Trevor A.; Meyerkort, Claire; Pennell, Craig E.
- Relation
- Scientific Reports Vol. 11, Issue July, no. 14826
- Publisher Link
- http://dx.doi.org/10.1038/s41598-021-94206-4
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2021
- Description
- It is well established that genetics, environment, and interplay between them play a crucial role in adult disease. We aimed to evaluate the role of genetics, early life nutrition, and the interaction between them, on optimal adult health. As part of a large international consortium (n ~ 154,000), we identified 60 SNPs associated with both birthweight and adult disease. Utilising the Raine Study, we developed a birthweight polygenic score (BW-PGS) based on the 60 SNPs and examined relationships between BW-PGS and adulthood cardiovascular risk factors, specifically evaluating interactions with early life nutrition. Healthy nutrition was beneficial for all individuals; longer duration of any breastfeeding was particularly associated with lower BMI and lower Systolic Blood Pressure in those with higher BW-PGS. Optimal breastfeeding offers the greatest benefit to reduce adult obesity and hypertension in those genetically predisposed to high birthweight. This provides an example of how precision medicine in early life can improve adult health.
- Subject
- adult health; genetics; early life nutrition; cardiovascular; SDG 3
- Identifier
- http://hdl.handle.net/1959.13/1456773
- Identifier
- uon:45264
- Identifier
- ISSN:2045-2322
- Rights
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Language
- eng
- Full Text
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