- Title
- Maternal Particulate Matter Exposure Impairs Lung Health and Is Associated with Mitochondrial Damage
- Creator
- Wang, Baoming; Chan, Yik-Lung; Liao, Jiayan; Chapman, David G.; Foster, Paul S.; Saad, Sonia; Chen, Hui; Oliver, Brian G.; Li, Gerard; Ho, Kin Fai; Anwer, Ayad G.; Smith, Bradford J.; Guo, Hai; Jalaludin, Bin; Herbert, Cristan; Thomas, Paul S.
- Relation
- Antioxidants Vol. 10, Issue 7, p. 1029-1029
- Publisher Link
- http://dx.doi.org/10.3390/antiox10071029
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2021
- Description
- Relatively little is known about the transgenerational effects of chronic maternal exposure to low-level traffic-related air pollution (TRAP) on the offspring lung health, nor are the effects of removing such exposure before pregnancy. Female BALB/c mice were exposed to PM2.5 (PM2.5, 5 µg/day) for 6 weeks before mating and during gestation and lactation; in a subgroup, PM was removed when mating started to model mothers moving to cleaner areas during pregnancy to protect their unborn child (Pre-exposure). Lung pathology was characterised in both dams and offspring. A subcohort of female offspring was also exposed to ovalbumin to model allergic airways disease. PM2.5 and Pre-exposure dams exhibited airways hyper-responsiveness (AHR) with mucus hypersecretion, increased mitochondrial reactive oxygen species (ROS) and mitochondrial dysfunction in the lungs. Female offspring from PM2.5 and Pre-exposure dams displayed AHR with increased lung inflammation and mitochondrial ROS production, while males only displayed increased lung inflammation. After the ovalbumin challenge, AHR was increased in female offspring from PM2.5 dams compared with those from control dams. Using an in vitro model, the mitochondria-targeted antioxidant MitoQ reversed mitochondrial dysfunction by PM stimulation, suggesting that the lung pathology in offspring is driven by dysfunctional mitochondria. In conclusion, chronic exposure to low doses of PM2.5 exerted transgenerational impairment on lung health.
- Subject
- air pollution; lung function; reactive oxygen species; mitochondrial dysfunction; asthma; SDG 3; SDG 11; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1456638
- Identifier
- uon:45252
- Identifier
- ISSN:2076-3921
- Rights
- This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/
- Language
- eng
- Full Text
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Goal 11: Sustainable Cities and Communities
Goal 3: Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 7 MB | Adobe Acrobat PDF | View Details Download |