- Title
- Effect of immune activation during early gestation or late gestation on inhibitory markers in adult male rats
- Creator
- Rahman, Tasnim; Weickert, Cynthia Shannon; Harms, Lauren; Meehan, Crystal; Schall, Ulrich; Todd, Juanita; Hodgson, Deborah M.; Michie, Patricia T.; Purves-Tyson, Tertia
- Relation
- NHMRC.APP1026070 http://purl.org/au-research/grants/nhmrc/1026070
- Relation
- Scientific Reports Vol. 10, no. 1982
- Publisher Link
- http://dx.doi.org/10.1038/s41598-020-58449-x
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2020
- Description
- People with schizophrenia exhibit deficits in inhibitory neurons and cognition. The timing of maternal immune activation (MIA) may present distinct schizophrenia-like phenotypes in progeny. We investigated whether early gestation [gestational day (GD) 10] or late gestation (GD19) MIA, via viral mimetic polyI:C, produces deficits in inhibitory neuron indices (GAD1, PVALB, SST, SSTR2 mRNAs) within cortical, striatal, and hippocampal subregions of male adult rat offspring. In situ hybridisation revealed that polyI:C offspring had: (1) SST mRNA reductions in the cingulate cortex and nucleus accumbens shell, regardless of MIA timing; (2) SSTR2 mRNA reductions in the cortex and striatum of GD19, but not GD10, MIA; (3) no alterations in cortical or striatal GAD1 mRNA of polyI:C offspring, but an expected reduction of PVALB mRNA in the infralimbic cortex, and; (4) no alterations in inhibitory markers in hippocampus. Maternal IL-6 response negatively correlated with adult offspring SST mRNA in cortex and striatum, but not hippocampus. These results show lasting inhibitory-related deficits in cortex and striatum in adult offspring from MIA. SST downregulation in specific cortical and striatal subregions, with additional deficits in somatostatin-related signalling through SSTR2, may contribute to some of the adult behavioural changes resulting from MIA and its timing.
- Subject
- disease model; neuroscience; schizophrenia; maternal immune activation (MIA)
- Identifier
- http://hdl.handle.net/1959.13/1456159
- Identifier
- uon:45189
- Identifier
- ISSN:2045-2322
- Rights
- Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2020.
- Language
- eng
- Full Text
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