- Title
- The nervous system: Orchestra conductor in cancer, regeneration, inflammation and immunity
- Creator
- Hondermarck, Hubert; Huang, Pearl S.; Wagner, John A.
- Relation
- FASEB BioAdvances Vol. 3, Issue 11, p. 944-952
- Publisher Link
- http://dx.doi.org/10.1096/fba.2021-00080
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2021
- Description
- Although the role of nerves in stimulating cellular growth and dissemination has long been described in tissue regeneration studies, until recently a similar trophic role of nerves in disease was not well recognized. However, recent studies in oncology have demonstrated that the growth and dissemination of cancers also requires the infiltration of nerves in the tumor microenvironment. Nerves generate various neurosignaling pathways, which orchestrate cancer initiation, progression, and metastases. Similarly, nerves are increasingly implicated for their regulatory functions in immunity and inflammation. This orchestrator role of nerves in cellular and molecular interactions during regeneration, cancer, immunity, and inflammation offers new possibilities for targeting or enhancing neurosignaling in human health and diseases.
- Subject
- cancer; immunity; inflammation; nerves; nervous system; regeneration; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1455540
- Identifier
- uon:45102
- Identifier
- ISSN:2573-9832
- Rights
- © 2021 The Authors. FASEB BioAdvances published by Wiley Periodicals LLC on behalf of The Federation of American Societies for Experimental Biology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- Language
- eng
- Full Text
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Goal 3: Good Health and Well-Being
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