- Title
- Exercise Preserves Physical Function in Prostate Cancer Patients with Bone Metastases
- Creator
- Galvão, Daniel A.; Taaffe, Dennis R.; Spry, Nigel; Cormie, Prue; Joseph, David; Chambers, Suzanne K.; Chee, Raphael; Peddle-Mcintyre, Carolyn J.; Hart, Nicolas H.; Baumann, Freerk T.; Denham, James; Baker, Michael; Newton, Robert U.
- Relation
- Medicine & Science in Sports & Exercise Vol. 50, Issue 3, p. 393-399
- Publisher Link
- http://dx.doi.org/10.1249/MSS.0000000000001454
- Publisher
- Lippincott Williams & Wilkins
- Resource Type
- journal article
- Date
- 2018
- Description
- Purpose: The presence of bone metastases has excluded participation of cancer patients in exercise interventions and is a relative contraindication to supervised exercise in the community setting because of concerns of fragility fracture. We examined the efficacy and safety of a modular multimodal exercise program in prostate cancer patients with bone metastases. Methods: Between 2012 and 2015, 57 prostate cancer patients (70.0 ± 8.4 yr; body mass index, 28.7 ± 4.0 kg·m−2) with bone metastases (pelvis, 75.4%; femur, 40.4%; rib/thoracic spine, 66.7%; lumbar spine, 43.9%; humerus, 24.6%; other sites, 70.2%) were randomized to multimodal supervised aerobic, resistance, and flexibility exercises undertaken thrice weekly (EX; n = 28) or usual care (CON; n = 29) for 3 months. Physical function subscale of the Medical Outcomes Study Short-Form 36 was the primary end point as an indicator of patient-rated physical functioning. Secondary end points included objective measures of physical function, lower body muscle strength, body composition, and fatigue. Safety was assessed by recording the incidence and severity of any adverse events, skeletal complications, and bone pain throughout the intervention. Results: There was a significant difference between groups for self-reported physical functioning (3.2 points; 95% confidence interval, 0.4–6.0 points; P = 0.028) and lower body muscle strength (6.6 kg; 95% confidence interval, 0.6–12.7; P = 0.033) at 3 months favoring EX. However, there was no difference between groups for lean mass (P = 0.584), fat mass (P = 0.598), or fatigue (P = 0.964). There were no exercise-related adverse events or skeletal fractures and no differences in bone pain between EX and CON (P = 0.507). Conclusions: Multimodal modular exercise in prostate cancer patients with bone metastases led to self-reported improvements in physical function and objectively measured lower body muscle strength with no skeletal complications or increased bone pain.
- Subject
- bone metastases; prostate cancer; randomized controlled trial; exercise; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1453655
- Identifier
- uon:44701
- Identifier
- ISSN:0195-9131
- Rights
- Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
- Language
- eng
- Full Text
- Reviewed
- Hits: 4026
- Visitors: 4205
- Downloads: 193
Collections
Goal 3: Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 295 KB | Adobe Acrobat PDF | View Details Download |