- Title
- Endovascular thrombectomy: tirofiban increases bleeding risk in acute stroke patients
- Creator
- Wu, Yuefei; Yin, Congguo; Yang, Jianhong; Jiang, Lin; Parsons, Mark W.; Lin, Longting
- Relation
- Stroke Vol. 49, Issue 11, p. 2783-2785
- Publisher Link
- http://dx.doi.org/10.1161/STROKEAHA.118.022919
- Publisher
- Lippincott Williams & Wilkins
- Resource Type
- journal article
- Date
- 2018
- Description
- Background and Purpose: This study aimed to explore safety of tirofiban in endovascular treatment of acute ischemic stroke. Methods: Two hundred eighteen ischemic stroke patients receiving endovascular thrombectomy were prospectively recruited, with 94 treated with intra-arterial tirofiban and 124 were not. The 2 groups were compared in terms of symptomatic intracranial hemorrhage (ICH) and fatal ICH rate by the χ2 test and logistic regression. Results: Patients treated with tirofiban compared with those without tirofiban had significantly higher rate of symptomatic ICH (14.6% versus 5.7%; P=0.027) and fatal ICH (8.8% versus 1.6%; P=0.014). Tirofiban-treated patients had increased odds of symptomatic ICH by 2.9-fold (95% CI, 1.1-7.5), and odds of fatal ICH increased by 5.9-fold (95% CI, 1.2-28.4). Conclusions: Tirofiban treatment increases risk of major ICH after endovascular thrombectomy for acute ischemic stroke in this nonrandomized study.
- Subject
- hemorrhage; intracranial hemorrhage; risk; stroke; thrombectomy; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1452875
- Identifier
- uon:44530
- Identifier
- ISSN:1524-4628
- Language
- eng
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