Testosterone to estradiol ratio and plaque inflammation: mechanistic insights and biomarker potential?

Title: Testosterone to estradiol ratio and plaque inflammation: mechanistic insights and biomarker potential?
Creator: Figtree, Gemma A.; Ngo, Doan T. M.; Bubb, Kristen J.
Relation: Cardiovascular Research Vol. 115, Issue 2, p. 255-257
Publisher Link: http://dx.doi.org/10.1093/cvr/cvy260
Publisher: Oxford University Press
Resource Type: journal article
Date: 2019
Description: Despite the now clear role of inflammation in atherosclerotic plaque development, progression and instability, our understanding of endogenous factors regulating this is limited. Our strategies for measuring inflammation relevant to the arterial wall remains relatively primitive, e.g. the highly sensitive, but non-specific C-reactive protein (CRP). Improved understanding of the specific factors upstream of inflammation has the potential to identify markers with higher specificity for atherosclerosis risk. New insights may also aid the development of novel therapeutic targets, which may act in a synergistic manner with current standard pharmacotherapy targeting lipids and neurohormonal abnormalities.
Subject: testosterone; estradiol ratio; plaque inflammation; mechanistic insights
Identifier: http://hdl.handle.net/1959.13/1451092
Identifier: uon:44090
Identifier: ISSN:0008-6363
Language: eng
Reviewed

		Thumbnail	File	Description	Size	Format