- Title
- The Effects of Increasing Fruit and Vegetable Intake in Children with Asthma on the Modulation of Innate Immune Responses
- Creator
- Hosseini, Banafsheh; Berthon, Bronwyn S.; Mattes, Joerg; Wood, Lisa G.; Jensen, Megan E.; McLoughlin, Rebecca F.; Wark, Peter A. B.; Nichol, Kristy; Williams, Evan J.; Baines, Katherine J.; Collison, Adam; Starkey, Malcolm R.
- Relation
- Nutrients Vol. 14, Issue 15, no. 3087
- Publisher Link
- http://dx.doi.org/10.3390/nu14153087
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2022
- Description
- Children with asthma are at risk of acute exacerbations triggered mainly by viral infections. A diet high in fruit and vegetables (F&V), a rich source of carotenoids, may improve innate immune responses in children with asthma. Children with asthma (3–11 years) with a history of exacerbations and low FV intake (≤3 serves/d) were randomly assigned to a high F&V diet or control (usual diet) for 6 months. Outcomes included respiratory-related adverse events and in-vitro cytokine production in peripheral blood mononuclear cells (PBMCs), treated with rhinovirus-1B (RV1B), house dust mite (HDM) and lipopolysaccharide (LPS). During the trial, there were fewer subjects with ≥2 asthma exacerbations in the high F&V diet group (n = 22) compared to the control group (n = 25) (63.6% vs. 88.0%, p = 0.049). Duration and severity of exacerbations were similar between groups. LPS-induced interferon (IFN)-γ and IFN-λ production showed a small but significant increase in the high F&V group after 3 months compared to baseline (p < 0.05). Additionally, RV1B-induced IFN-λ production in PBMCs was positively associated with the change in plasma lycopene at 6 months (rs = 0.35, p = 0.015). A high F&V diet reduced asthma-related illness and modulated in vitro PBMC cytokine production in young children with asthma. Improving diet quality by increasing F&V intake could be an effective non-pharmacological strategy for preventing asthma-related illness by enhancing children’s innate immune responses.
- Subject
- childhood asthma; innate immunity; fruit and vegetables; carotenoids
- Identifier
- http://hdl.handle.net/1959.13/1449305
- Identifier
- uon:43636
- Identifier
- ISSN:2072-6643
- Rights
- © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
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