An overview of circular RNAs

Title: An overview of circular RNAs
Creator: Awasthi, Rajendra; Singh, Anurag Kumar; Mishra, Gaurav; Maurya, Anand; Chellappan, Dinesh Kumar; Gupta, Gaurav; Hansbro, Philip Michael; Dua, Kamal
Relation: Circular RNAs: Biogenesis and functions p. 3-14
Relation: Advances in Experimental Medicine and Biology 1087
Publisher Link: http://dx.doi.org/10.1007/978-981-13-1426-1_1
Publisher: Springer
Resource Type: book chapter
Date: 2018
Description: Circular RNAs (cirRNAs) are long, noncoding endogenous RNA molecules and covalently closed continuous loop without 5′–3′ polarity and polyadenylated tail which are largely concentrated in the nucleus. CirRNA regulates gene expression by modulating microRNAs and functions as potential biomarker. CirRNAs can translate in vivo to link between their expression and disease. They are resistant to RNA exonuclease and can convert to the linear RNA by microRNA which can then act as competitor to endogenous RNA. This chapter summarizes the evolutionary conservation and expression of cirRNAs, their identification, highlighting various computational approaches on cirRNA, and translation with a focus on the breakthroughs and the challenges in this new field.
Subject: cirRNA; circular RNAs; gene expression; translation
Identifier: http://hdl.handle.net/1959.13/1448353
Identifier: uon:43386
Identifier: ISBN:9789811314261
Language: eng